Case studies

Research library

65+ peer-reviewed
publications.

Clinical trials, platform research, technical papers, and conference proceedings published by the ORamaVR team and independent research institutions.

2024 – 2025

Validation studyRobotic surgery

ERMIS: Enhanced Robotic Medical Immersive Simulator — Validation Pilot Study

ORamaVR Research Team

Authorea Preprints

Team trainingEmergency Medicine

Non-linear, Team-based VR Training for Cardiac Arrest Care with Enhanced CRM Toolkit (iREACT)

Kentros M, Kamarianakis M, Cole M, Popov V, Protopsaltis A, Papagiannakis G

Eurographics 2025 — Short Papers

Geometric AlgebraAI / LLM

Geometric Algebra Meets Large Language Models: Instruction-Based Transformations of Separate Meshes in 3D, Interactive and Controllable Scenes

Kolyvakis P, Kamarianakis M, Papagiannakis G

arXiv preprint — cs.CV

Medical XRSIGGRAPH Asia

Computational Medical Extended Reality (CMXR): Pioneering the Future of Healthcare Through Computational Medicine and Extended Reality

Papagiannakis G et al.

SIGGRAPH Asia 2024 — Courses

Platform science

Research Article — AIP Publishing (2024)

ORamaVR Research Team

AIP Publishing — 2024

InfrastructureEdge computing

Edge-driven Docker Registry: Facilitating XR Application Deployment

Makris A, Psomakelis E, Korontanis I, Theodoropoulos T, Diou C, Anagnostopoulos D, Tserpes K et al.

Computing — Springer, Vol. 106, pp. 3479–3501

Geometric AlgebraNetworking

GA-Unity: A Production-Ready Unity Package for Seamless Integration of Geometric Algebra in Networked Collaborative Applications

Kamarianakis M, Lydatakis N, Papagiannakis G

arXiv preprint — cs.GR

PhysicsNetworking

Decoupled Edge Physics Algorithms for Collaborative XR Simulations

Kamarianakis M, Papagiannakis G

Technical Report — 2024

Medical XRReview

A Computational Medical XR Discipline

Papagiannakis G, Greenleaf W, Cole M, Zhang M, Datta R, Delahaye M, Grigoriou E, Kamarianakis M, Protopsaltis A, Bijlenga P, Magnenat-Thalmann N, Tsiridis E, Kenanidis E, Vamvakidis K, Koutelidakis I, Kannape OA

arXiv preprint — cs.GR (2024 revision)

Robotic surgeryDigital Twin

VR Isle Academy: A VR Digital Twin Approach for Robotic Surgical Skill Development

Filippidis A, Marmaras N, Maravgakis M, Plexousaki A, Kamarianakis M, Papagiannakis G

arXiv preprint — cs.RO

RCTOrthopaedics

Effectiveness of VR Compared to Video Training on Acetabular Cup and Femoral Stem Implantation Accuracy in Total Hip Arthroplasty

Kenanidis E, Boutos P, Voulgaris G, Zgouridou A, Gkoura E, Gamie Z, Papagiannakis G, Tsiridis E

International Orthopaedics — Vol. 48, Issue 3, pp. 625–633

A Network Application Approach Towards 5G and Beyond Critical Communications Use Cases

Apostolakis KC, Valera-Muros B, di Pietro N, Garrido P, del Teso D, Kamarianakis M, Tomas PR, Khalili H, Panizo L, Diaz Zayas A, Protopsaltis A, Margetis G, Mangues-Bafalluy J, Requena-Esteso M, Gomes AS, Cordeiro L, Papagiannakis G, Stephanidis C

Frontiers in Communications and Networks

Clinical trials & medical applications

Team trainingEmergency Medicine

Non-linear, Team-based VR Training for Cardiac Arrest Care with enhanced CRM Toolkit (iREACT)

Kentros M, Kamarianakis M, Cole M, Popov V, Protopsaltis A, Papagiannakis G

arXiv preprint — cs.HC

Cognitive HealthClinical trial

The Effect of Physical Exercise with Cognitive Training on Inflammation and Alzheimer’s Disease Biomarkers of Mild Cognitive Impairment Patients

Mouzakidis C et al.

Neuroscience Applied — Elsevier

RCTOrthopaedics

Effectiveness of VR Compared to Video Training on Acetabular Cup and Femoral Stem Implantation Accuracy in Total Hip Arthroplasty

Kenanidis E, Boutos P, Voulgaris G, Zgouridou A, Gkoura E, Gamie Z, Papagiannakis G, Tsiridis E

International Orthopaedics — Vol. 48, Issue 3, pp. 625–633

Educational research

Training for Better Transfer in an Online Competency-Based Higher Education Program: Technology’s Role in Preparing the Next Generation Workforce

Advances in Educational Technologies and Instructional Design

Usability studyEmergency Medicine

Development and Usability Testing of a Fully Immersive VR Simulation for REBOA Training

Birrenbach T, Wespi R, Hautz WE, Berger J, Schwab PR, Papagiannakis G, Exadaktylos AK, Sauter TC

International Journal of Emergency Medicine

Cognitive HealthClinical trial

Effects of Virtual Reality Physical and Cognitive Training Intervention on Cognitive Abilities of Elders with Mild Cognitive Impairment

Baldimtsi E, Mouzakidis C, Karathanasi EM, Verykouki E, Hassandra M, Galanis E, Hatzigeorgiadis A et al.

Journal of Alzheimer’s Disease Reports — Vol. 7, Issue 1, pp. 1475–1490

Cognitive HealthClinical trial

VRADA Training System as a Non-Pharmacological Dual Intervention to Alleviate Symptoms of the Pathophysiology of Mild Cognitive Impairment

Mouzakidis C et al.

Brain Disorders — Elsevier

DevelopmentCOVID-19

Virtual Reality Medical Training for COVID-19 Swab Testing and Proper Handling of PPE: Development and Usability

Birrenbach T et al.

Frontiers in Virtual Reality

RCT ProtocolPerioperative

A Digital Health Intervention for Stress and Anxiety Relief in Perioperative Care: Protocol for a Feasibility Randomized Controlled Trial

Kondylakis H et al.

JMIR Research Protocols

Randomised trialCOVID-19

Effectiveness and Utility of VR Simulation as an Educational Tool for Safe Performance of COVID-19 Diagnostics: Prospective, Randomized Pilot Trial

Birrenbach T, Zbinden J, Papagiannakis G, Exadaktylos AK, Müller M, Hautz WE, Sauter TC

JMIR Serious Games — Vol. 9, Issue 4, e29586

Cognitive HealthFeasibility study

A Virtual Reality App for Physical and Cognitive Training of Older People With Mild Cognitive Impairment: Mixed Methods Feasibility Study

Hassandra M, Galanis E, Hatzigeorgiadis A, Goudas M, Mouzakidis C, Karathanasi EM, Petridou N, Tsolaki M, Zikas P, Evangelou G, Papagiannakis G et al.

JMIR Serious Games — Vol. 9, Issue 1, e24170

RCTOrthopaedics

Virtual Reality Simulation Facilitates Resident Training in Total Hip Arthroplasty: A Randomized Controlled Trial

Hooper J et al.

The Journal of Arthroplasty — Vol. 34, Issue 10, pp. 2278–2283

Platform & core technology

MAGES 4.0: Accelerating the world’s transition to VR training and democratizing the authoring of the medical metaverse

Zikas P, Protopsaltis A, Lydatakis N, Kentros M, Geronikolakis S, Kateros S, Kamarianakis M, Evangelou G, Filippidis A, Grigoriou E, Angelis D, Tamiolakis M, Dodis M, Kokiadis G, Petropoulos J, Pateraki M, Papagiannakis G

IEEE Computer Graphics and Applications

A computational medical XR discipline

Papagiannakis G, Greenleaf W, Cole M, Zhang M, Datta R, Delahaye M, Grigoriou E, Kamarianakis M, Protopsaltis A, Bijlenga P, Magnenat-Thalmann N, Tsiridis E, Kenanidis E, Vamvakidis K, Koutelidakis I, Kannape OA

arXiv preprint — cs.GR

RoboticsDigital Twin

VR Isle Academy: A VR Digital Twin Approach for Robotic Surgical Skill Development

Filippidis A, Marmaras N, Maravgakis M, Plexousaki A, Kamarianakis M, Papagiannakis G

arXiv preprint — cs.RO

PlatformSIGGRAPH

MAGES 3.0: Tying the knot of medical XR

Papagiannakis G, Zikas P, Lydatakis N, Kateros S, Kentros M, Geronikolakis E, Kamarianakis M, Kartsonaki I, Evangelou G

ACM SIGGRAPH 2020 Immersive Pavilion

PlatformSIGGRAPH Asia

Transforming medical education and training with VR using M.A.G.E.S.

Papagiannakis G, Lydatakis N, Kateros S, Georgiou S, Zikas P

ACM SIGGRAPH Asia 2018 Posters

Technical & algorithm research

Geometric AlgebraAI

Geometric Algebra Meets Large Language Models: Instruction-Based Transformations of Separate Meshes in 3D, Interactive and Controllable Scenes

Kamarianakis M, Papagiannakis G

Geometric AlgebraNetworking

GA-Unity: A Production-Ready Unity Package for Seamless Integration of Geometric Algebra in Networked Collaborative Applications

Kamarianakis M, Lydatakis N, Papagiannakis G

arXiv preprint — cs.GR

PhysicsNetworking

Decoupled Edge Physics Algorithms for Collaborative XR Simulations

Kamarianakis M, Papagiannakis G

arXiv / Technical Report

Geometric AlgebraAI

UniSG^GA: A 3D scenegraph powered by Geometric Algebra unifying geometry, behavior and GNNs towards generative AI

Kamarianakis M, Protopsaltis A, Angelis D, Zikas P, Kentros M, Papagiannakis G

ENGAGE workshop, CGI 2023

Soft-body physics

Progressive tearing and cutting of soft-bodies in high-performance virtual reality

Kamarianakis M, Protopsaltis A, Angelis D, Tamiolakis M, Papagiannakis G

ICAT-EGVE 2022 — International Conference on Artificial Reality and Telexistence

Soft-body physicsMobile VR

Deep Cut: An all-in-one Geometric Algorithm for Unconstrained Cut, Tear and Drill of Soft-bodies in Mobile VR

Kamarianakis M, Lydatakis N, Protopsaltis A, Petropoulos J, Tamiolakis M, Zikas P, Papagiannakis G

arXiv preprint — cs.GR

NetworkingCollaboration

Never ‘Drop the Ball’ in the Operating Room: An efficient hand-based VR HMD controller interpolation algorithm for collaborative, networked virtual environments

Kamarianakis M, Lydatakis N, Papagiannakis G

CGI 2021 — ENGAGE Workshop

AR-Assisted Surgical Care via 5G Networks for First Aid Responders

Kamarianakis M, Protopsaltis A, Papagiannakis G

IEEE CAMAD 2022 — International Workshop on Computer Aided Modeling and Design of Communication Links

Conference & education papers

SIGGRAPHCOVID-19

Covid-19 — VR Strikes Back: innovative medical XR training

Zikas P, Kamarianakis MN, Kartsonaki I, Lydatakis N, Kateros S, Kentros M, Geronikolakis E, Evangelou G, Apostolou A, Catilo PA, Papagiannakis G

ACM SIGGRAPH 2021 — Immersive Pavilion

Visual scriptingThe Visual Computer

Scenior: An Immersive Visual Scripting system based on VR Software Design Patterns for Experiential Training

Zikas P, Papagiannakis G, Lydatakis N, Kateros S, Ntoa S, Adami I, Stephanidis C

The Visual Computer — Vol. 36, pp. 1965–1977

EducationGeometric Algebra

Project Elements: A computational entity-component-system in a scene-graph pythonic framework, for a neural, geometric computer graphics curriculum

Papagiannakis G, Kamarianakis M, Protopsaltis A, Angelis D, Zikas P

Eurographics 2023 — Education Papers

Full bibliography of 65+ publications available on request. Additional papers in progress.

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